Honeywell True HEPA 50250 Air Purifier

The Honeywell 50250 (Model 50250-S) is Honeywell's most powerful HEPA air cleaner, producing more clean air for the money than other Honeywell models. The permanent True HEPA filter removes 99.97% of allergens and particles as small as 0.3 microns, and can now be vacuumed to extend its life and save on filter replacements. A carry handle makes the unit portable, giving you fresh air and germ protection where you need it. Designed for larger rooms up to 390 sq ft.
MSRP $263.00 Selling Price $209.99
In stock

This product provides relief from: Asthma, Bacteria & Germs, Dust Allergies, Dust Mites, Fragrances & Odors, Mold & Mildew, Pet Dander, Pollen

Honeywell's highest powered HEPA air purifier - The Honeywell 50250 True HEPA Air Purifier ‐ Model #50250-S.The Honeywell 50250-S comes with long-lasting HEPA filtration so that you can enjoy the benefits of cleaner air and save on costly filter replacements. The True HEPA filter captures 99.97% of airborne particles down to 0.3 microns, and can simply be vacuumed twice a year (depending on use) instead of replaced. Of course, you can still replace the HEPA every 1-5 years if the filter gets clogged, damaged, or if you prefer to buy new. The unit also comes with an activated carbon pre-filter to trap larger airborne particles and reduce odors and gases, keeping air fresh while protecting the HEPA. The economical pre-filter is not washable, and will require replacement every 3 months. For larger rooms up to 390 square feet.

Tip: Replace the pre-filter when the indicator light turns red. This will keep the machine performing at its best, and alleviate undue particle stress on the HEPA.

Doctors often recommend Honeywell air purifiers to their patients because they trust in Honeywell's performance. The Honeywell 50250-S effectively removes airborne allergens, particles and other contaminants that can aggravate allergies, asthma, and other respiratory disorders. The 50250-S is AHAM Certified¹ to clean air in rooms up to 390 square feet. As air circulates through the unit (several times an hour), microscopic particles are removed, including dust, dust mite allergen, pollen, pet dander, mold spores, soot, tobacco smoke, light household odors and gases, and even some germs, viruses and bacteria. Honeywell goes a step further. Its patented 360° air intake and discharge maximizes air cleaning efficiency, and its SurroundSeal™ technology helps prevent the particles circulating through the unit from bypassing the HEPA and leaching back into the room.

The Honeywell 50250-S control panel comes with a backlit 3-speed control knob, plus filter status indicators and reset buttons. Customers like the attractive simplicity of the control panel. Use the rotary dial to switch between 3 air cleaning speeds – Sleep (low), Day (medium) or Turbo (high), or to turn the unit off. The dial is backlit with a blue light that goes on when the machine is running. Intelli-Check™ Filter Indicators provide a convenient guide as to when to check or clean the HEPA, and when to replace the pre-filter.

The Honeywell 50250-S is quietest on "Low" and loudest on "High". Sound levels range between 49-62 dBA (decibels), depending on fan speed. The unit runs at about the same noise level as the Honeywell 50150-N on low and medium speeds, but is bit more loud than the 50150-N at the highest speed. Some customers who use the 50250-S in their bedrooms prefer to run the unit on "High" during the day (or for a few hours before retiring), and then switch it to "Low" for overnight use. However and wherever you choose to use it, customers categorically report they sleep better, breathe better, have less coughs, sneezes, and sinus infections, wake up free of congestion, itchiness, and runny noses, and generally feel much better using the Honeywell 50250-S air purifier.  5-Year Limited Mfr. Warranty.


  • Popular air purifier at a great value
  • Helps reduce exposure to particulates that cause allergic reaction or respiratory distress
  • Effective in small to medium-sized rooms
  • AHAM Certified¹ to provide clean air in rooms up to 390 sq ft (about 17'x22')
  • Long-lasting True HEPA filter for cost effectiveness
  • SurroundSeal™ means far less particles bypass the HEPA
  • Activated carbon pre-filter for light odors and gases ‐ also protects HEPA
  • 360° air intake (sides) and output (top), designed for maximum delivery of filtered air
  • 3-speed rotary dial (backlit with blue light)
  • Intelli-Check™ filter change/clean reminders and reset buttons
  • Easy access to filter area (bottom) ‐ quick filter change
  • Remember to:
    • Replace the pre-filter every 3 months
    • Vacuum HEPA filter twice a year (or replace every 1-5 years)
  • Compact, round design ‐ 19"x18" Dia., 20 lbs
  • Top hand grip for easy portability
  • Ozone free


¹ This Honeywell air purifier is certified by the Association of Home Appliance Manufacturers (AHAM) for the Clean Air Delivery Rate (CADR) that has been assigned to the unit. AHAM's Portable Electric Room Air Cleaner Verification Program provides assurance to the public, through the presence of the AHAM Verification Seal, that the manufacturer's claimed CADR ratings have been independently verified in accordance with ANSI/AHAM Standard AC-1.

More Information

Honeywell's highest-powered HEPA cleaner yields the greatest cleaning power for the money. CADR rated at 250, this workhorse is fast and hungry, gobbling up the most airborne particles with virtually no leakage because of Honeywell's terrific SurroundSeal™ technology.

Room Size

390 sq. ft. (approx. 17' x 22')

Recommended For

Allergies, asthma, some odors, smoke and gases, overall air quality

Best Fit

Recommended for those with more serious allergies, asthma, or respiratory issues, or anyone requiring the cleanest air

True HEPA Filtration


Particle Filtration Efficiency

99.97% to 0.3 microns

Particle Removal

Dust, dust mite allergen, pollen, pet dander, mold spores

Gas and Odor Removal

Light odors and smoke

VOC Removal


Optional Filters


Unique Features / Benefits

SurroundSeal™ technology minimizes air leaks for cleaner air. Very easy filter change. Low maintenance.

CADR: Dust rating


CADR: Pollen rating


CADR: Smoke rating


ACH (air changes per hour)

Not available

Airflow (cubic feet per minute)

253 cfm

Filtration System

True HEPA filter with wrap-around activated carbon pre-filter

Number of Filters to Replace

1 pre-filter (also 1 HEPA, if not vacuumed periodically)

Replace HEPA Filter

Long-lasting, if vacuumed periodically, otherwise every 1-5 years, depending on use

Replace Pre-Filter

Every 3 months

Replace Other Filters


Dimensions (H x W x D)

19.0"H x 18" Dia.

Color choices


Product Weight

20 lbs

Packaged Weight

22.1 lbs

Shipping Weight

38 lbs

Noise Level - (min-max decibels)

49-62 dBA


Manual ‐ rotary dial (with a blue backlight when running)

Remote Control


Number of Fan Speeds


LCD Display




Programmable Cycles or Timer


Sleep Mode


Auto Fan Mode (auto adjusts based on air quality)


Particle, Gas or VOC Detector


Filter Status Indicator

Yes ‐ 2 LEDs (for HEPA filter & pre-filter) alert when filter change needed

Filter Reset function


Other Indicators


Other Features

SurroundSeal™ technology minimizes particle leakage

Casters or Handles

Top Hand Grip

Air Inlet

Lower section ‐ all around

Air Outlet

Top ‐ discharges air upward

Housing Construction

Sturdy plastic case with large, heavy-duty plastic "bolt" to open, close & secure the filter compartment

Fan / Motor Assembly

Not available

Energy Consumption (watts)

170 W

Power Requirements

115 V, 60 Hz

Power Plug

2-prong polarized plug


1.4 Amps

Energy Star®


AHAM-certified CADR


Approvals / Other Certifications

UL listed. California ARB certified.

Ozone Emission


Manufacturer's Warranty

5-Year Limited

Honeywell 50250-S True HEPA Air Purifier Instructions

Please see Owner's Manual tab for setup and operating instructions, plus full instructions on changing the filters. For best air flow, locate the unit at least 3 feet (1 meter) from any wall or furniture.

General on Pre-Filter:

  • Replace the pre-filter approximately every 3 months.
  • Pre-filter is Honeywell part # 38002 (or equivalent).
  • The pre-filter absorbs odors and captures large airborne particles that enter the air cleaner. Therefore, regularly changing the pre-filter will keep your air cleaner performing at its best, and preserve the life of the HEPA filter.

General on HEPA Filter:

  • The 50250-S comes with a long-lasting HEPA filter that is easy to clean – just vacuum at least twice a year (depending on use) for optimum performance.

  • If you have an older 50250 without a Permanent HEPA filter, or you do not maintain the HEPA filter, or if it becomes damaged or permanently clogged (or if you just prefer a new filter), you can choose to replace the HEPA with either the:

    1. Honeywell HEPA part # 24000. This is the full-size, non-stackable HEPA replacement (so only 1 is required for the 50250, 50250-N or 50250-S), and is available through National Allergy, or

    2. Honeywell "F" type HEPA filter, part # HRF-F1 (single pack) or HRF-F2 (2-pack). These are the short-size, stackable HEPA replacements – three (3) are required for the 50250, 50250-N or 50250-S (not available through National Allergy).

  • Regular maintenance helps to prolong the life of the HEPA filter. Keep the area surrounding the air purifier clean, and be sure to change the pre-filter approximately every 3 months.

NOTE:   Do NOT immerse the pre-filter or HEPA filter in water - they are NOT washable.

Click here to view the Owner's Manual for the Honeywell 50250 True HEPA Air Purifier (model 50250-S).


Rated 4.80 out of 5 based on 6 reviews.

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November 10
Somewhat noisy but makes a significant difference.
July 8
Our last version of this air filter lasted 10 years which I was very satisfied with. My only compliant was our new unit had some black marks on the exterior.
May 4
Very pleased. Great machine. Replacing a 15 year old.
October 27
With in thirty minutes, I could sense a big difference in the air. I am buying one more to completely cover my home.
July 13
High quality machine, hope it last 20 years like the one I purchased 20 years back!
December 3
Great unit and easy to set-up.
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